Commentary Video Podcast

AstraZeneca’s very strange data release around their COVID-19 vaccine

At first, I was confused since some of the press releases state that it was 90% effective, others stated it was 60% effective, and yet other press releases came up with an average of 70% effective. These were supposed to be the results from a single clinical trial! Remarkably, this was only the start of the confusion on this vaccine’s data. 

, Pandemic Pondering Blog

‘The end of this nightmare is in sight’

Moderna said they can manufacture 20 million doses before the end of this year and at least 500 million doses in 2021 ... If both the Pfizer and Moderna vaccines are authorized, that would give the US 40 million doses before January.

, Pandemic Pondering Blog

Coronavirus Vaccine Update From the FDA

[PODCAST] The FDA's Peter Marks, MD, PhD talks with JAMA Editor Howard Bauchner, MD on vaccine progress as of Oct. 5 and prospects for pre-election interference in the FDA approval process.

, JAMA Network (Oct. 5)

Warp Speed for COVID-19 Vaccines: Why are Children Stuck in Neutral?

Emory University pediatrician Dr. Evan Anderson argues that delaying vaccine trials in children will hamper their education, health, and emotional well being as well as prolong the pandemic. "... the role of children in SARS-CoV-2 transmission has clearly been underappreciated," he writes.

, Clinical Infectious Diseases

These Coronavirus Trials Don’t Answer the One Question We Need to Know

Will vaccine trials answer the most important question: Will the vaccines prevent moderate and severe COVID disease? The trials look only at mild disease as the endpoint. And nothing will be known abouut their efficacy in children, adolescents, and pregnant women because these populations are excluded from trials.

, The New York Times

NIH ‘Very Concerned’ About Serious Side Effect in Coronavirus Vaccine Trial

With very little information about the one recent serious adverse effect in the AstraZeneca vaccine trial, NIH scientists are circumspect regarding the safey of the vaccine -- not to say that it may not be safe, but they need more information before being assured that the trial should proceed in the U.S. 

, Kaiser Health News

Guidelines for Covid-19 Vaccine Deployment

A podcast with editors of NEJM covering how COVID-19 vaccines are being developed, discussing a recent setback of one case of a possibe neurological adverse effect, and then talking about vaccine global deployment -- how and to whom first. 

, New England Journal of Medicine

Pfizer's Latest Stealthy Move Could Help It Win the Coronavirus Vaccine Race

With multiple SARS-CoV-2 vaccines in testing, Pfizer may be betting that positioning itself to prevail in the long run will be a better strategy than necessarily being first to market. With multiple vaccine candiates in its portfolio, one may emerge later as more efficacious than what comes first. 

, The Motley Fool

Scientists see downsides to top COVID-19 vaccines from Russia, China

These vaccines, using modified adenovirus type 5 (Ad5) viral vectors, could potentially have limited efficacy. Many adenoviruses commonly circulate in the population to cause the common cold. Thus, many people may have immunity to Ad5, eliminating the vector carrying the SARS-CoV-2 genes before it could insert its payload into cells. A group at McMaster University is developing an inhaled Ad5 COVID vaccine, "theorizing it could circumvent pre-existing immunity issues." But isn't the respiratory tract exactly where a cold virus would induce immunity?

, Reuters

Letter from Infectious Diseases Society of America to FDA on approving a COVID vaccine

The IDSA urges the FDA to approve and license any vaccine based on completed phase 3 trials and not through an Emergency Use Authorization. However, if the FDA issues an EUA, the IDSA urges it to use both internal and independent external experts to review full safety and efficacy data.

, Infectious Diseases Society of America

Do-it-Yourself Vaccines for COVID-19

Two bioethicists explore the ethics, legal aspects, and what knowledge may be gained or lost when scientists self-administer untested products developed as COVID-19 vaccines.

, Scientific American

[VIDEO] Coronavirus Update With Ezekiel J. Emanuel, MD, PhD

Ezekiel Emanuel, MD, PhD, of the University of Pennsylvania's Perelman School of Medicine, Department of Medical Ethics and Health Policy, discusses logistics, policy, & ethis of COVID vaccine distribution (at 15:28-25:58; Recorded August 19, 2020)

, JAMA Network

Encouraging News About Coronavirus Immunity

Excellent, inciteful compilation of and commentary on reports regarding natural and vaccine-induced immunity to SARS-CoV-2 in not-too-technical language (with links to reports)

, In the Pipeline by Derek Lowe

The Treatment That Could Crush Covid

One of the most promising therapies uses “medicinal signaling cells,” or MSCs, which are found on blood vessels throughout the body. Early trials show signaling cells eliminate the virus, calm the immune response and repair tissue damage.

, Wall Street Journal Opinion/Commentary

Pandemic vaccine trials: expedite, but don’t rush

The article argues for adherence to existing structures for drug/vaccine development in the quest for a SARS-CoV-2 vaccine. "...consent is not suficient  for the justification of additional risk," the author asserts.

, Research Ethics

A Vaccine Reality Check

So much hope is riding on a breakthrough, but a vaccine is only the beginning of the end.

, The Atlantic

Even without a Covid-19 vaccine, there's reason for hope

... even without a vaccine, there is reason for hope that a medical solution to the crisis will soon be at hand. It will likely take the form of anti-Covid drugs that will be able to treat patients newly infected and prevent others from becoming ill. These drugs can likely help us bridge the gap between where we are today -- with only masks, hand hygiene and physical distancing to protect us -- to where we hope to be tomorrow -- with a vaccine in hand.


An Old Vaccine May Help Against Coronavirus

The COVID-19 outbreak in the United States will continue to "get worse before it gets better," but the situation might improve as clinicians gain a better understanding of how to treat the virus in the absence of a vaccine or a cure, experts said Tuesday.